Hypertension
Conditions
Interventions
DEX?:Dexmedetomidine 0.5 µg/kg was administered within 10min followed by infusion at 0.4 µg/kg/h
MID?:Midazolam 2mg was administered within 10min followed by infusion of saline
C?:Equal volume of saline was administered
Sponsors
Taizhou Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >= 65 years with a clear history of hypertension; 2. The patients to be operated on under the spinal epidural anesthesia; 3. Patients with ASA grade II-III; 4. The subjects understood and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with systolic blood pressure >= 180mmhg and / or diastolic blood pressure >= 110mmhg; 2. Patients with history of secondary hypertension and diabetes; 3. Patients with sinus bradycardia, poor atrioventricular conduction, or allergic to the study drug were found by ECG; 4. Patients with hyperthyroidism and other diseases that may affect heart function; 5. Patients with history of central nervous system diseases; 6. Patients with a history of serious cardiopulmonary diseases, such as cardiomyopathy, cor pulmonale, etc; 7. Patients with vascular or skin diseases who are unable to measure upper limb blood pressure 8. Patients with severe liver and kidney dysfunction (liver enzyme > 3 times the upper limit of normal or estimated glomerular filtration rate < 30ml / min); 9. Subjects who ingested caffeine or alcohol within 24 hours; 10. Subjects who have participated in or are participating in other clinical studies within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| baroreflex sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure;diastolic blood pressure;mean arterial pressure;pulse oxygen saturation;heart rate; | — |
Countries
China
Contacts
Public ContactXiaodan Wang
Department of Anesthesiology, Taizhou Hospital, Zhejiang Province
Outcome results
None listed