Cardiovascular events after non-cardiac surgery
Conditions
Interventions
Intensive intraoperative blood pressure management group:Target intraoperative MAP at or above 80 mmHg
Conventional intraoperative blood pressure management group:Target intraoperative MAP at or above 65 mmHg
Sponsors
Southern Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The age is more than or equal to 45 years old; 2. It is planned to carry out large-scale abdominal operation under general anesthesia (the estimated operation time is more than 2 hours, and the postoperative hospitalization time is more than 2 days); 3. The patient has one or more of the following four diseases: (1) Coronary heart disease; (2) Stroke; (3) Peripheral arterial disease; (4) Congestive heart failure; (5) NT proBNP was more than 200 pg / ml or BNP was more than 92 mg / L before operation; (6) The preoperative troponin level was higher than the upper limit of normal range, or the patient had two or more of the following cardiovascular risk factors: (7) Chronic kidney disease (CR > 133 µ mol / L or 1.5 mg / dl before operation); (8) Diabetes requiring medication; (9) Smoking (continued for at least 2 years); (10) Aged 65 years and above; (11) Hypertension requiring medication; (12) Hypercholesterolemia.
Exclusion criteria
Exclusion criteria: 1. Patients with ASA grade >= 5; 2. Severe hypertension patients with poor preoperative control (systolic blood pressure > 180mmhg or diastolic blood pressure > 110mmhg); 3. Patients with end-stage renal disease requiring renal replacement therapy; 4. Patients with acute cardiovascular and cerebrovascular events (including heart failure, acute coronary syndrome and stroke in the past 1 month); 5. Patients diagnosed as sepsis before operation; 6. Patients who need to receive vasoactive drugs before operation; 7. Patients who are participating in another intervention clinical study; 8. Patients who have participated in this study; 9. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major adverse cardiac events (a composite of myocardial injury/infarction, new-onset clinically important arrhythmia, heart failure, stroke, cardiac arrest, and all-cause death after surgery); | — |
Secondary
| Measure | Time frame |
|---|---|
| Major non-cardiovascular complications;Days alive and out of hospital;Disability-free survival; | — |
Countries
China
Contacts
Public ContactKexuan Liu
Southern Hospital of Southern Medical University
Outcome results
None listed