Glioma
Conditions
Interventions
Group A:Conventional fractionated concurrent radiotherapy and chemotherapy
Group B:Low fractionated concurrent radiotherapy and chemotherapy
Sponsors
The First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. WHO grade III-IV glioma patients who underwent total or partial resection; 2. Patients with clear consciousness and KPS score >= 50; 3. Patients with life expectancy > 6 months; 4. Patients aged 18-70 years; 5. HGB >= 90 g/L, WBC >= 3.0 *10^9/L, ANC >= 1.5*10^9/L, PLT>= 50*10^9/L, SCR <= 1.5 * upper normal limit, TBIL <= 1.5 * upper normal limit, AST and alt <= 1.5 * upper normal limit; 6. Patients who sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who have had or are currently suffering from other malignant tumors within 5 years, except for cervical carcinoma in situ, non melanoma skin cancer and superficial bladder tumor; 2. Pregnant or lactating patients; 3. Patients participating in other clinical trials at present or within 4 weeks before inclusion; 4. Patients with a history of immunodeficiency, or other acquired or congenital immunodeficiency diseases, or organ transplantation history; 5. Patients with radiotherapy history; 6. Patients with serious complications, such as hypertension, coronary heart disease or mental history, or patients with serious allergic history; 7. According to the judgment of the researchers, there are patients with serious hazards to the safety of patients or accompanying diseases that affect the completion of the study; 8. The researchers asked the patients out of the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;progression-free time; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival;Adverse Effects Rate; | — |
Countries
China
Contacts
Public ContactJiang Xin
Department of Radiotherapy, the First Hospital of Jilin University
Outcome results
None listed