Establishment of the network in disorders of brain–gut interactions of non-erosive reflux disease by multimodal neuroimaging

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000033638

Enrollment

Unknown

Registered

2020-06-07

Start date

2020-06-01

Completion date

Unknown

Last updated

2020-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-erosive reflux disease

Interventions

NERD group:Nil

RH group:Nil

FH group:Nil

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Between the ages of 18 and 70 years. (2) GERD-Q score was more than 8 in patients with reflux related symptoms. (3) After double dose PPI treatment for 8 weeks, reflux symptoms are not improved.

Exclusion criteria

Exclusion criteria: (1) Patients with esophageal hiatal hernia, reflux esophagitis, Barrett's esophagus, upper gastrointestinal tumor, peptic ulcer and other organic diseases are found by gastroscopy. (2) Gastroesophageal reflux disease secondary to systemic diseases. (3) There are contraindications of MRI. (4) There are serious complications of heart, liver, kidney and brain. (5) High resolution esophageal manometry indicates severe esophageal motility abnormality. (6) Definite diagnosis of craniocerebral organic disease, mental disease, and patients receiving psychotherapy.

Design outcomes

Primary

Measure	Time frame
T1WI;diffusion tensor imaging (DTI);resting-state functional MRI;	—

Secondary

Measure	Time frame
GERD-Q score;SCL90;self-Rating Anxiety Scale;self-rating depression scale;stress assessment scale;life event scale;Pittsburgh sleep quality index;	—

Countries

China

Contacts

Public ContactChuan Zhang

digestivezhang@163.com+86 13717683638

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026