osteoarthritis
Conditions
Interventions
Group A:ntraoperative tranexamic acid (intravenous 1g+ intra-articular 1g) + postoperative oral administration of 3 doses of tranexamic acid (oral administration of 2gTXA at 2, 8 and 14h after surgery
Group B:Intraoperative tranexamic acid (intravenous 1g+ intra-articular 1g) + postoperative oral administration of 3 doses of tranexamic acid (oral 2g of placebo pills 2, 8 and 14h after surgery)
Sponsors
Department of Orthopedics, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
19 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as knee osteoarthritis requiring unilateral primary TKA surgery. 2. American Society of Anesthesiologists degree before operation: I~III grade. 3. Over 18 years of age.
Exclusion criteria
Exclusion criteria: 1. People who are allergic to tranexamic acid; 2. There was an operative knee deformity (buckling deformity > 20 degrees; Varus and valgus deformity BBB 0 20 degrees) and stiffness of joints; 3. Revision partial or total knee replacement, suppurative arthritis or post-traumatic arthritis; 4. Serious cardiovascular and respiratory diseases; Kidney and liver failure, history of kidney transplantation; 5. Refusing to participate in or accept blood products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative blood loss or total blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Invisible blood loss;Intraoperative blood loss;Inflammatory markers;Fibrinolytic marker;range of motion;Blood transfusion rate (%);pain score;LOS(length of stay); | — |
Countries
China
Contacts
Public ContactKang Pengde
Department of Orthopedics, West China Hospital, Sichuan University
Outcome results
None listed