Hepatocellular carcinoma, combined portal vein tumor thrombosis
Conditions
Interventions
TACE+RT:TACE followed by radiotherapy
RT+TACE:RT followed by TACE
Sponsors
Third Affiliated Hospital of the Second Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Patients with combined portal carcinoma thrombosis of the liver assessed as unresectable by the same medical group; 3. Preoperative liver function Child A or B, thrombinogen time (PT) less than 4 seconds for normal controls. Gastroscopic esophageal veins without severe varicose, inactive gastrointestinal ulcers. No hepatic encephalopathy or/and significant ascites. Kidney function and cardiopulmonary function are basically normal. Hemoglobin >=90g/L, white blood cell count >=3.0x10^9/L, neutrophil count >=1.5x10^9/L, platelet count >=60x10^9/L; 4. Life expectancy greater than three months, no pregnancy, no HCV, HIV or syphilis infection, able to understand the circumstances of the study and have signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Those who have received chemotherapy, TACE, radiation therapy, targeted drugs, biological therapy, or participated in clinical trials of other drugs or instruments prior to admission to the group; 2) The tumor has developed distant metastases, e.g., lung, brain, bone, etc.; 3) Severe varicose veins of the esophagogastric floor with a tendency to bleed from the gastrointestinal tract or a previous history of haemorrhage from the gastrointestinal tract; (4) Those who, in the opinion of the investigator, are otherwise inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival;Progression-free survival; | — |
Countries
China
Contacts
Public ContactCheng Shuqun
Third Affiliated Hospital of the Second Military Medical University
Outcome results
None listed