Premature ovarian insufficiency
Conditions
Interventions
experimental group:Arterial infusion of human amniotic epithelial cells
Sponsors
International Peace Maternity and Child Health Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Subjects who met the diagnostic criteria of POI: aged 40 IU / L (repeat twice every 4 weeks). 2. Patients who are diagnosed as infertile and require fertility; 3. Blood ß - hCG negative subjects; 4. Subjects who have not received other clinical trials within 3 months before the clinical study; 5. The patient agreed to participate in the study and signed the informed consent before participating in any research related activities.
Exclusion criteria
Exclusion criteria: 1. Patients with other malignant tumor history in the past 5 years; 2. Patients with severe functional damage of important organs; 3. The object of abnormal karyotype; 4. Patients with abnormal coagulation mechanism; 5. Patients with severe pelvic adhesion; 6. Patients whose acute and chronic inflammation of gynecology has not been controlled; 7. Patients with congenital adrenal hyperplasia; 8. Patients with Cushing's syndrome; 9. Patients with thyroid dysfunction; 10. Patients with hyperprolactinemia; 11. Patients with pituitary amenorrhea or hypothalamic amenorrhea; 12. Patients with thrombophlebitis, including venous thrombosis and arterial thrombosis; 13. Patients with ovarian cyst or ovarian surgery; 14. Objects with high tumor markers; 15. Pregnancy or lactation; 16. Patients receiving other treatments that may affect the efficacy and safety of stem cells; 17. Patients with severe drug allergy; 18. Patients with abnormal blood routine, coagulation time, liver and kidney function, ECG, chest film, hepatitis B and hepatitis C virus index, HIV, TPAB and other abnormalities were examined one month before operation. 19. Patients with abnormal mental diseases; 20. The patient participates in any other clinical study using intervention drugs or examination procedures at the same time; 21. Patients considered unsuitable by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function routine;kidney function;Electrolyte;blood test routine;Full set of sex hormones;Gynecological examination;Gynecology three-dimensional ultrasound; | — |
Countries
China
Contacts
Public ContactDongmei Lai
International Peace Maternity and Child Health Hospital
Outcome results
None listed