Osteoporosis
Conditions
Interventions
Group 2:Nutritional supplements of vitamin D (400 IU/d) combined with calcium (500mg/d)
Group 3:Nutritional supplements of MK-7(72ug/d) combined with vitamin D (400 IU/d) and calcium (500mg/d)
Sponsors
School of Public Health, Shanghai Jiaotong University
Eligibility
Sex/Gender
Female
Age
50 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 50-65 years; 2. Women with menopause more than 3 years; 3. Women with reduced bone mass (t-values of BMD of lumbar and hip joints are less than - 1 and more than - 2.5).
Exclusion criteria
Exclusion criteria: 1. Subjects with any diseases which may effect the metabolism of vitamin K, vitamin D, calcium and bone, shch as chronic kidney disease, hyperthyroidism, hypothyroidism, celiac disease, metabolic bone disease, etc. 2. Subjects with any critical diseases, such as cancer, chronic or paroxysmal atrial fibrillation, history of operation of coronary artery bypass grafting or coronary artery revascularization, miocardial infarction or stroke < 6 months, etc. 3. Subjects intake any drugs or supplements which may effect calcium or bone metabolism within one months, such as antibiotic, glucocorticoid, estrogen, diuretics, proton pump inhibitors, vitamin K supplements, vitamin D supplements, calcium supplements, calcium antagonists, vitamin K antagonists, vitamin D antagonists, diphosphate, etc. 4. Subjects who are participating in other clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density;BAP;OC;ucOC;PINP;NTX;CAC score;CCA-IMT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Calcium modulator hormone;Serum calcium;Serum vitamin D;Serum vitamin K;Blood glucose;Blood lipids;Blood pressure;Body fat;Waist circumference;BMI;Sleep;Physical activity;Intake of energy and nutrients; | — |
Countries
China
Contacts
Public ContactXue Li
School of Public Health, Shanghai Jiaotong University
Outcome results
None listed