Knee Osteoarthritis
Conditions
Interventions
Sponsors
Shanghai Sixth People's hospital
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: All consenting knee OA patients meeting the following criteria are screened for inclusion: 1. between the ages of 40 years and 70 years old (non-inclusive); 2. who have had bilateral knee pain persisting for more than 6 months (also present for most of previous month); 3. have Kellgren and Lawrence grade 2 or 3 knee OA (documented by anteroposterior and lateral view X-rays); 4. have completed physical therapy for at least 3 months; and 5. are able to communicate in Mandarin Chinese.
Exclusion criteria
Exclusion criteria: 1. Candidate participant has co-morbidities, such as systemic or inflammatory joint disease (rheumatoid arthritis); history of crystalline arthritis (gout and pseudogout) or neurological joint disease (neuroarthropathies, Charcot joint); other muscle, joint, or nervous system diseases that affect lower limb function; 2. has needle phobia; 3. has evidence of immunosuppression or acute infection; 4. has or has had cancer or tumours; 5. has a bleeding disorder or is receiving anticoagulation or antiplatelet therapy; 6. has a platelet count of = 6.2 mmol/L and triglycerides of >2.3 mmol/L; 8. presence of other medical conditions that preclude participation, including contraindications to MRI, such as pacemaker, ferromagnetic aneurysm clips, cochlear implant, or any other metallic foreign bodies; 9. pregnant; 10. has a body mass index (BMI) of > 40 kg/m2; 11. unable to make at least 10 research appointments within 24 months; 12. has a history of any mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC scale;Volume of medial tibial cartilage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of knee pain during walking;Intermittent and persistent osteoarthritis pain;Knee joint injury and OA outcome score;The amount of celecoxib taken orally; | — |
Countries
China
Contacts
Public ContactZhang Changqing
Shanghai Sixth People's hospital
Outcome results
None listed