Intraoperative systemic versus local corticosteroids in improving postoperative pain after total knee arthroplasty: a prospective, randomized, and controlled study

The clinical study of fast recovery during the surgical stage of arthroplasty

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000033490

Enrollment

Unknown

Registered

2020-06-02

Start date

2020-07-20

Completion date

Unknown

Last updated

2020-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced knee osteoarthritis

Interventions

systemic corticosteroids group:use of systemic corticosteroids during the operation of primary total knee arthroplasty

local corticosteroids group:use of local corticosteroids during the operation of primary total kne arthropalsty

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: All patients undergoing primary total knee arthroplasty at the participating institution(Guangdong Provincial People's Hospital) will be potentially eligible for this study.

Exclusion criteria

Exclusion criteria: 1. Objects of alcohol and drug abuse; 2. Patients who are allergic to dexamethasone; 3. Patients younger than 18 years old; 4. Patients who use glucocorticoids daily; 5. Patients who use strong opioids daily (morphine, fentanyl, hydromorphone, ketoprostone, methadone, nicomorphine, oxycodone or pethidine); 6. Patients with history of serious heart disease (NYHA. 2); 7. Patients with renal insufficiency; 8. Patients with active peptic ulcer; 9. Patients with HbA1c > 8; 10. Patients with rheumatoid arthritis; 11. Patients with nervous or mental diseases that may affect pain perception; 12. Patients with cognitive impairment; 13. the researchers believe that patients are unlikely to comply with the test requirements after randomization; 14. Patients who are receiving the investigational product as part of another clinical trial.

Design outcomes

Primary

Measure	Time frame
Vas for pain while walking one day after operation;	—

Secondary

Measure	Time frame
VAS for pain at rest;VAS for pain while walking;VAS for pain while maximal actively knee flexion;Dosage of morphine analgesics after operation;Incidence of nausea and vomiting (PONV);Antiemetic dosage;Knee swelling;Maximum knee flexion;Plasma C-reactive protein (CRP);Plasma IL-6;Plasma D-dimer;Fasting blood glucose;Hospital stay;knee society score (KSS);Wound healing;Infection;	—

Countries

China

Contacts

Public ContactLi Qingtian

Guangdong Provincial People's Hospital

laykington@sina.com+86 18820109789

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026