Acute Ischemic Stroke
Conditions
Interventions
experimental group:Use butylphthalide
control group:nil
Sponsors
Jingjiang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. The patient's age > 18 years; 2. The patient must be admitted to the hospital within 24 hours of the onset of symptoms; 3. The patient's physical examination conforms to AIS diagnostic criteria after admission and is finally confirmed by CT or MRI. The symptoms of AIS are consistent with one or more of the following symptoms: (1) Sudden weakness or numbness on one side of the body, with or without facial numbness; (2) Skewed corners; (3) Unclear spitting or aphasia; (4) Eye gaze; (5) Loss of vision or blurred vision; (6) Dizziness combined with nausea and vomiting; (7) Severe headache or vomiting that has not previously occurred; (8) Disturbance of consciousness or twitching of the limbs. 4. The patient or the patient's agent can and is willing to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. The mRS score> 1 before this stroke; 2. There are intracranial hemorrhagic diseases: cerebral hemorrhage, subarachnoid hemorrhage, etc.; 3. Patients treated with drugs containing butylphthalide after the onset of illness; 4. Patients with a history of coagulopathy and systemic bleeding, patients with a history of thrombocytopenia or neutropenia; 5. With chronic liver disease, liver and kidney dysfunction, ALT increased (greater than 3 times the upper limit of normal), blood creatinine increased (greater than 2 times the upper limit of normal); 6. Patients who cannot cooperate with 2 MRI examinations to evaluate the new CMBs; 7. Patients with severe cardiopulmonary disease or bradycardia (heart rate below 60 beats / min), sick sinus syndrome; 8. Patients whose life expectancy is less than 3 months or unable to complete the study due to other reasons; 9. Those who have a history of drug allergies or food allergies and are known to be allergic to the drug ingredients in this study; 10. Patients who other researchers think are not suitable for participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3 months MRS;NIHSS on discharge;New cerebral hemorrhage; | — |
Countries
China
Contacts
Public ContactDing Yunlong
Jingjiang People's Hospita
Outcome results
None listed