Functional constipation
Conditions
Interventions
Sponsors
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) >=60 years old; 2) Functional constipation Roman III diagnostic standard; 3) Constipation after six months of combined treatment with oral drugs or biofeedback therapy; 4) No severe cardiac insufficiency (cardiac function level II or above) and basically normal liver and kidney functions; 5) At least 2 weeks after the patient received the last treatment; 6) The expected survival time is longer than 12 months; 7) Cooperate to observe adverse events and therapeutic effects; 8) Written informed consent signed by me or his legal representative; 9) No previous history of abdominal surgery; 10) Normal coagulation function.
Exclusion criteria
Exclusion criteria: 1) The patient has any doubts about the technique or has a history of other risks; 2) The patient is in the terminal stage of the disease; 3) The patients were involved in other clinical trials three months before intestinal flora transplantation; 4) Have participated in any other flora treatment before enrollment; 5) Hepatitis b, tuberculosis, syphilis, HIV positive or any infectious disease in the acute phase; 6) Cardiac function level II or above, transaminase increase more than twice the normal upper limit, renal insufficiency CKD3 or below; 7) Fever temperature above 38 degree C or clinically significant active infection; 8) Hemoglobin < 60 g/L, neutrophil absolute value < 1.5x10^9/L, PT prolonged for more than 1.5 seconds; People with severe immune deficiency; 9) Obvious cardiovascular and cerebrovascular abnormalities or heart disease with increased risk of ventricular arrhythmias as determined by the researchers; 10) Relevant clinical contraindications identified by the investigator during the trial that may affect subject compliance and/or completion of trial-related procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora 16S rDNA sequencing;Number of independent defecation;Bristol stool form scale;Constipation assessment scale;patient assessment of constipation symptom;knowles-eccersley-scott-symptom;patient assessment of constipation quality of life questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-rating anxiety scale;Self-rating Depression Scale;Immunological indicators;Inflammatory indicators; | — |
Countries
China
Contacts
Public ContactXiping Ding
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Outcome results
None listed