femoral head necrosis
Conditions
Interventions
Gold Standard:Clinical features and image data
of 
by 
Sponsors
Honghui Hospital, Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Have received or are receiving corticosteroid treatment; 2. Drinking history of more than 5 years; 3. Progressive hip pain, worsening when standing or walking or accompanied by limited hip movement; 4. Imaging examination: X film The display and CT showed extensive osteoporosis with osteosclerosis or cystic changes, or femoral head collapse, crescent sign, and normal or narrow joint space. MRI examination shows that the T1-weighted femoral head weight-bearing area shows a line-like low signal, or a crescent-shaped uneven signal or band-shaped low signal with a clear boundary; T2 weighted shows a high signal, or a double line formed with a slightly lower signal surrounding the uneven Sign, or collapse and deformation of the femoral head, acetabular sclerosis, cystic changes, and marginal osteophyte. Diagnostic criteria: meet with item 1, 3, and 4 is hormonal femoral head necrosis; meet item 2, 3, and 4 is alcoholic femoral head necrosis.
Exclusion criteria
Exclusion criteria: The case group: History of femoral neck fracture or hip dislocation before onset; history of seronegative arthritis such as rheumatism, rheumatoid arthritis, and osteoarthritis; persons engaged in diving and aviation; and obvious familial genetic diseases. The control group: Select healthy medical personnel whose age, gender, race, and place of residence matched the cases; those with no history of hip pain and joint dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma metabolome;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactHeping Zhao
Honghui Hospital, Xi'an Jiaotong University
Outcome results
None listed