total hip replacement
Conditions
Interventions
K Group:After the placement of hip joint prosthesis, the joint capsule was sutured, and then injected with ropivacaine 200mg + adrenaline 0.1mg + ketorolac tromethamine 30mg (the normal saline was mix
Kiv Group:After the placement of hip joint prosthesis, the joint capsule was sutured and then injected with ropivacaine 200mg + adrenaline 0.1mg (normal saline mixed with 60ml cocktail analgesic solut
C group:After the placement of hip joint prosthesis, the joint capsule was sutured and then injected with ropivacaine 200mg and epinephrine 0.1mg around the joint capsule and incision (the normal sali
Sponsors
Department of Anesthesiology, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who choose to undergo unilateral primary total hip arthroplasty and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are contraindicated to ketorolac tromethamine injection, such as allergic history, peptic ulcer history, etc.; 2. Patients who are allergic to any of the drugs used in this study; 3. Patients with history of opioid use, alcohol or drug abuse within 3 months; 4. Patients with moderate or more hip joint deformities (inward and outward turnover, flexion deformity) or other pathological conditions of the operative side of the limb; 5. Patients who could not complete the visual analogue scale to evaluate pain; 6. Patients who were not considered by the researchers to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score of the first hip flexion about 12 hours after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative opioid use;The dosage of postoperative remedial morphine hydrochloride;The time of first remedial morphine hydrochloride;The VAS scores of patients in resting and active (hip bending) state, PACU, 6h, 12h, 24h, 48h, 72h and the day of discharge were recorded;20 subjects (K group, KIV group) were randomly selected from the treatment group with ketorolac tromethamine injection. 4 ml of venous blood was collected at 0.5 h, 1 h, 2 h, 3 h, 6 h, 24 h after ketorolac tromethamine injection was given to study the pharmacokinetic parameters of ketorolac trometha;Muscle strength of quadriceps femoris and mobility of hip joint before and after operation;Occurrence of adverse events;The number of sleep interruptions per night from the day before operation to the day of discharge;The first time of exhaust and eating after operation;The first time for patients to go to the ground after operation;QOR15 rating scale.; | — |
Countries
China
Contacts
Public ContactJing Yang
Department of Anesthesiology, West China Hospital, Sichuan University
Outcome results
None listed