preeclampsia
Conditions
Interventions
Experimental group:VD600IU/d+Ca500mg/d+aspirin 100 mg/d
Control group:VD200IU/d+Ca500mg/d+aspirin 100 mg/d
Sponsors
Qingdao Women and Children's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-40 years old, 12-14 weeks pregnant: 2. Low dietary calcium intake(<1000mg/d); 3. Singleton pregnancy; 4. HIV(-); 5. Healthy HBV carriers can be included; 6. Fixed home address for follow-up.
Exclusion criteria
Exclusion criteria: 1. Liver dysfunction; 2. Those who did not use standardized treatment at the beginning; 3. Hyperparathyroidism, silicosis, malignancy, severe kidney disease, gastrointestinal disease, coronary heart disease, mental illness or alcoholism; 4. Patients with trauma or surgery in the near future (within one month); 5. Serum corrected calcium concentration >2.65 mmol/L, total serum bilirubin >40 umol/L or serum creatinine>250 umol/L; 6. Those who used corticosteroids or immunosuppressive drugs or took VD and calcium supplements in the previous month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of preeclampsia;Adverse outcome of newborn;serum 25(OH)D level; | — |
Countries
China
Contacts
Public ContactWang Qiuzhen
Qingdao University
Outcome results
None listed