Prostate cancer
Conditions
Interventions
Single-arm:SBRT
Sponsors
Cancer Hospital of Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients over 18 years old; 2. Patients with primary prostate cancer confirmed by pathology; 3. Risk stratification: Patients with low risk (ct1-t2a, PSA < 10NG / ml, Gleason score <=6) who refuse to actively monitor patients or patients with good / bad prognosis and some high risk (ct2b-t3a, PSA 10-40ng / ml, Gleason score 7-8) who refuse to actively monitor patients; 4. Patients with ECoG score of 0-2; 5. Prostate volume <=100cc; 6. Patients with IPSS score <18; 7. Patients who fully understand this study, can complete all treatment, have follow-up conditions and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications of MRI; 2. Patients who received transurethral prostatectomy within 6 months; 3. Image staging shows n + or M0; 4. Patients with ulcerative colitis, Crohn's disease, ataxia telangiectasia or systemic lupus erythematosus; 5. Patients with previous radiotherapy of pelvic cavity or prostate and surrounding organs; 6. Patients with new cancer within 5 years (except for early skin basal cell carcinoma); 7. Patients who had started endocrine therapy before entering the group; 8. Objects with fertility but refusing contraception; 9. Patients participating in other clinical trials at present or within four weeks before inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute GU and GI toxicities; | — |
Secondary
| Measure | Time frame |
|---|---|
| Late toxicities;Quality of Life;2-year biochemical-relapse free survival; | — |
Countries
China
Contacts
Public ContactNingning Lu/ Nianzeng Xing/ Yexiong Li
Cancer Hospital of Chinese Academy of Medical Sciences
Outcome results
None listed