The effect of dexmedetomidine on perioperative neurocognitive dysfunction in elderly patients: a randomized controlled trial.

The effect of dexmedetomidine on perioperative neurocognitive dysfunction in elderly patients

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000033367

Enrollment

Unknown

Registered

2020-05-29

Start date

2020-05-28

Completion date

Unknown

Last updated

2020-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative neurocognitive disorders

Interventions

experimental group:Dexmedetomidine

control group:0.9% Nacl

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients aged over 40 years; 2. Asai-III patients diagnosed as gastrointestinal cancer; 3. Patients with informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of central nervous system disease or psychological disease; 2. Patients with a long history of taking sedatives or analgesics or antidepressants; 3. Patients with a history of alcohol and drug abuse; 4. Serious hearing or visual impairment; 5. Patients with severe conduction block and MMSE score < 23; 6. Patients with serious adverse events during operation; 7. Patients with contraindications and allergies to dexmedetomidine; 8. Patients with secondary operation.

Design outcomes

Primary

Measure	Time frame
microRNA320;IGF-1 miRNA;IGF-1;APP;Aß;incidence of PND;	—

Secondary

Measure	Time frame
hemodynamic fluctuations;Postoperative pain;	—

Countries

China

Contacts

Public ContactYanlin Bi

Department of Anesthesiology, Dongyuan District, Qingdao Municipal Hospital, Shandong Province

yanlinbi68@sina.cn+86 18661675610

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026