STEMI patients with high thrombus burden
Conditions
Interventions
Microcatheter-targeted thrombolysis group:Microcatheter-targeted intracoronary thrombolysis
Thrombus aspiration group:Conventional intracoronary thrombus aspiration
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Between 18 and 80 years old; 2. STEMI patients undergoing primary PCI within 12 hours after the onset of symptoms; 3. Total occlusion of the culprit artery with high thrombus burden after guidewire passes the lesion (TIMI thrombus grade >= 3).
Exclusion criteria
Exclusion criteria: 1. Rescue-PCI; 2. Previous coronary bypass grafting; 3. The predicted survival time less than 12 months due to non-cardiac diseases; 4. Active bleeding, bleeding diseases or known bleeding tendency within 6 months; 5. Sever hepatic or renal dysfunction; 6. Pregnancy or lactation; 7. Uncontrolled hypertension (>180/100mmHg); 8. Previous hemorrhagic stroke in any time or ischemic stroke within 3 months; 9. Cardiopulmonary resuscitation; 10. No informed consent or failure to complete all the treatment or follow-up according to the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of maior adverse cardiovascular events during six-month follow up;The incidence of stroke or bleeding during 30-day follow up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Myocardial blush grade after procedure;ST segment resolution after procedure;Ratio of TIMI flow grade 3;The incidence of MACEs during 30-day follow up;The incidence of MACEs during three-month follow up;Side-branch occlusion; | — |
Countries
China
Contacts
Public ContactJingang Zheng
China-Japan Friendship Hospital
Outcome results
None listed