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Effect of LCZ696 (sacubitril/valsartan) on serum TMAO level and intestinal flora in elderly patients with chronic heart failure

Effect of LCZ696 (sacubitril/valsartan) on serum TMAO level and intestinal flora in elderly patients with chronic heart failure

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000033344
Enrollment
Unknown
Registered
2020-05-28
Start date
2020-07-01
Completion date
Unknown
Last updated
2020-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic heart failure

Interventions

case series:Nil

Sponsors

Zhejiang Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. 24 elderly patients with chronic heart failure admitted to the Department of Cardiology of our hospital; 2. The diagnostic standard of chronic heart failure was Framingham heart failure (1971); 3. All patients were fed a low salt and low fat diet; 4. According to the 2018 China heart failure guidelines, patients who receive standard drug treatment, including sakubatrevalsartan, ß receptor blocker, diuretic, aldosterone receptor antagonists, are given antiarrhythmic drugs or drugs to control ventricular rate as required; 5. All patients need to sign informed consent; 6. Inclusion criteria: (1) Aged >= 60 years; (2) Chronic heart failure, NYHA II-III; (3)NT-proBNP >= 600pg/ml.

Exclusion criteria

Exclusion criteria: 1. Patients with acute attack or acute heart failure of chronic heart failure; 2. Patients with acute coronary syndrome within 6 months; 3. Patients with infection, malignant tumor, obvious primary diseases of liver and kidney, and autoimmune diseases; 4. Patients with pericardial tamponade, pulmonary embolism and refractory end-stage heart failure; 5. Patients with gastrointestinal diseases or malabsorption and malnutrition (MNA-SF 0-7 points) were assessed by mini nutrition scale; 6. Patients combined with antibiotics or probiotics; 7. Patients who died within 72 hours after admission; acute myocardial infarction; active myocarditis; cardiogenic shock; severe ventricular arrhythmia; patients with allergic constitution; 8. Other patients: such as respiratory diseases, cerebral vascular embolism, migraine, etc. may affect the intestine.

Design outcomes

Primary

MeasureTime frame
Intestinal flora;TMAO;

Countries

China

Contacts

Public ContactYanhua Xiong

Zhejiang Hospital

xyh557_557@126.com+86 13605806835

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026