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Significance of plasma exosome transcriptome in differential diagnosis of benign and malignant lung nodules

Significance of plasma exosome transcriptome in differential diagnosis of benign and malignant lung nodules: a multicenter, prospective, non-interventional study

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000033339
Enrollment
Unknown
Registered
2020-05-28
Start date
2020-05-27
Completion date
Unknown
Last updated
2020-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary nodule

Interventions

Gold Standard:Pathological diagnosis
criptome

Sponsors

Cancer Hospital of Chinese Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients older than 18 years old, male and female unlimited; 2. Patients to be operated; 3. Preoperative imaging showed that patients with chest nodules (if multiple nodules, the maximum diameter of the main focus was less than 3cm), and postoperative pathological diagnosis was clear; 4. Patients with complete clinical and prognostic information; 5. Informed consent of patients.

Exclusion criteria

Exclusion criteria: 1. Patients with other kinds of tumors; 2. Patients with any serious or uncontrolled systemic diseases that significantly affect the risk / benefit balance of patients, including uncontrolled hypertension, hepatitis B, hepatitis C, AIDS, rheumatic immune diseases, etc; 3. Patients with a history of alcohol or drug abuse; 4. Pregnant or lactating women; 5. The researchers think it is not suitable for the participants.

Design outcomes

Primary

MeasureTime frame
Plasma exosome RNA expression level;SEN, SPE, ACC, AUC of ROC;

Countries

China

Contacts

Public ContactWei Guo

Cancer Hospital of Chinese Academy of Medical Sciences

guowei@cicams.ac.cn+86 18601139134

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026