stroke
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Patients meet the diagnostic criteria of cerebral infarction with integrated Chinese and western medicine; (2) Patients diagnosed with cerebral infarction with upper limb movement dysfunction by MRI or CT; (3) Patients aged 30 to 80 years old male and female; (4) No limitation on the degree of limb dysfunction within 1 week after the first onset of disease course; (5) Clear consciousness without obvious aphasia or cognitive dysfunction; (6) No limb deformity, motor dysfunction or sensory dysfunction before onset; (7) Without skull defect or other physical diseases, and can withstand the detection for 1h; (8) Sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with subarachnoid hemorrhage, cerebral embolism, lacunar cerebral infarction and cerebral trauma, who have serious systemic diseases such as cardiopulmonary diseases and cannot tolerate rehabilitation treatment; (2) Patients with more than two or more cerebral infarction, or with cognitive, verbal, psychological, mental, visual and auditory disorders; (3) Contraindication of transcranial magnetic stimulation (TMS) and magnetic resonance (MRI) examination, such as pacemaker, metal implant, etc., in pregnant or lactating women; (4) Patients with motor dysfunction before onset should apply drugs (antiepileptic drugs, sedative and hypnotic drugs, etc.) to change the excitability of cerebral cortex; (5) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| motor evoked potential (MEP);short-interval intracortical inhibition;short-interval intracortical inhibition;120%resting motor threshold ;Fugl-Meyer motor assessment of the upper extremity; | — |
Secondary
| Measure | Time frame |
|---|---|
| shoulder abduction and finger extension;The National Institutes of Health Stroke Scale; | — |
Countries
China
Contacts
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine