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Conditions
Interventions
Nalbuphine Group :Intravenous nalbuphine
Fentanyl Group :Intravenous fentanyl
Sponsors
Chinese people's Liberation Army General Hospital of Eastern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years old and American Society of Anesthesiologists Physical Status Classification (ASA grade) <= II; 2. Diagnosed as infected necrotizing pancreatitis; 3. Patients stay awake and cooperate well without mechanical ventilation; 4. Patients receive PED without contraindication; 5. Informed consents were obtained from enrolled patients.
Exclusion criteria
Exclusion criteria: 1. Death is deemed imminent and inevitable; 2. Pregnancy (confirmed or suspected); 3. Patients are allergy to opioids; 4. A percutaneous measurement of oxygen saturation (SpO2) by pulse oximetry of <= 90% when delivering oxygen through a nasal cannula at 5L/min; 5. Patients with severe cardiovascular, renal or hepatic disease defined as (1) NYHA functional class III-IV, (2) ALT and/or AST level more than 1.5 times the upper limit of normal value or (3) creatinine level exceeds the upper limit of normal value.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| qualified rate of analgesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Respiratory rate;oxygen saturation;diastolic pressure;systolic pressure;Heart rate variability;incidence of operation interruption;incidence of adverse events;Total does of analgesic; | — |
Countries
China
Contacts
Public ContactLu Ke
Jinling Hospital affiliated to Nanjing University
Outcome results
None listed