Colon cancer
Conditions
Interventions
Control group :Chemotherapy alone
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~75 years; 2. ECOG (Eastern Cooperative Oncology Group) 0-1 and expected survival period for 6 months or more; 3. Pathological diagnosis of colon cancer adenocarcinoma; 4. At least one measurable objective tumor lesions which could be evaluated; 5. Primary and metastatic tumors exist at the same time, and distant metastases are not resectable; 6. ANC >= 1.5*10^9/L, PLT>= 90*109/L, HB>= 90g/L, TBI<= 1.5(UNL); ALT, AST <= 2.5(ULN), Cr <= 1.0(ULN) screening within 7 days; 7. No systemic chemotherapy; 8. Patients with voluntary participation, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Operation intervention required for perforation, bleeding and obstruction of intestinal cavity; 2. Multiple primary colorectal carcinoma; 3. Malignant peritoneal effusion or metastatic carcinoma of the peritoneum; 4. Uncontrolled pleural effusion; 5. Malignant tumour of the past five years with other organizations to source, but the full treatment of cervical carcinoma in situ and except skin basal cell carcinoma and squamous cell carcinomas; 6. With brain metastasis or meningeal metastasis; 7. Pregnancy or breast-feeding women; 8. Alcohol or drug addictions; 9. There is an important organ failure or other serious diseases, including coronary artery disease, symptomatic cardiovascular disease or myocardial infarction within 12 months; serious neurological or psychiatric history; severe infection; actively disseminated vascula blood coagulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| The first progression time after diagnosis;The first progression time after randomization;Tolerance to treatment;Living quality;Objective response rate;Postoperative complications;The proportion of surgical intervention in control group;The detection of tumor biomarker and survival analysis; | — |
Countries
China
Contacts
Public ContactXinxiang Li
Shanghai Cancer Center, Fudan University
Outcome results
None listed