Multiple system atrophy
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. The patients who met the most likely MSA (probable MSA) diagnosis in the second edition of the diagnostic standard proposed by Gilman et al; 2. Patients who voluntarily participated in the study and signed the informed consent; 3. Patients who can complete clinical evaluation, venous blood collection and lumbar puncture; 4. Patients without cognitive impairment or bed rest at baseline.
Exclusion criteria
Exclusion criteria: 1. Patients with cerebrovascular history, severe head injury history and other neuropsychological history; 2. Patients who refuse to follow up; 3. Patients over 75 years old; 4. With family history of ataxia or Parkinson's syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of the disease;Laboratory inspection;Demography;Medical history;Non-motor symptoms;Neuroelectrophysiological indicators;Imaging inspection; | — |
Countries
China
Contacts
West China Hospital of Sichuan University