depression
Conditions
Interventions
Drug Group:medication
rTMS Group:body surface localized transcranial magnetic stimulation therapy
Precise localized rTMS group:precise localized rTMS treatment
Sponsors
Department of Psychosomatic Medicine, the First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. With the consent of the Ethics Committee of the First Affiliated Hospital of the Air Force Military Medical University, patients who have informed consent for the risk benefit of participating in the treatment of this project and signed a written informed consent; 2. Patients who meet the symptom criteria, severity criteria, course criteria, and exclusion criteria for the diagnosis of depression (international classification of diseases-10, ICD-10); 3. The Hamilton Depression Scale 17 (HAMD-17) score >= 18 points and the Pain Scale (VAS) score >= 1 point; 4. Aged 18-65 years; 5. Han nationality; 6. Right-handed; 7. Have not used antidepressants, antipsychotics or other psychotropic drugs in the past six months.
Exclusion criteria
Exclusion criteria: 1. Patients who suffering from other mental disorders that meet the diagnostic criteria of ICD-10; 2. Patients with severe physical diseases, such as epilepsy, liver and kidney function damage, diabetes, blood system diseases, etc.; 3. There are cardiovascular system diseases or abnormal ECG (including QTc >= 500 ms), or are taking drugs that may significantly affect the QT interval; 4. Narrow-angle glaucoma; 5. Those who have used ECT treatment six months before enrollment; 6. Those who have or have suffered from drug-induced malignant syndrome and severe delayed dyskinesia; 7. Those who have serious suicide attempts, or those who are seriously excited; 8. Those who cannot take the medicine as directed by the doctor, or who do not have a guardian; 9. Women who are pregnant or breastfeeding or plan to become pregnant; 10. Those with head trauma with consciousness disorder exceeding 5 minutes history; 11. Contraindications of magnetic resonance scanning (metal foreign bodies in the body, electronic devices, etc.); 12. Those with metal implants in the mouth, head, etc..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD;VAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| head MRI; | — |
Countries
China
Contacts
Public ContactHuaning Wang
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed