Slow transit constipation
Conditions
Sponsors
Tianjin Union Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Chronic constipation according to Rome III criteria, defined as two or fewer spontaneous, complete bowel movements (SCBMs) per week for a minimum of 6 months; 2. Aged >= 18 years; 3. BMI: 18.5-25 kg/m2; 4. Slow colonic transit confirmed by colonic transit test (colonic transit time (CTT) > 48 hours); Normal anorectal manometry with no evidence of dyssynergia and confirmed ability to expel rectal balloon; 5. Traditional treatment with dietary modification, laxatives (including osmotic and stimulant laxatives), and biofeedback tried over the past 6 months without success;
Exclusion criteria
Exclusion criteria: 1. Bowel constipation due to innate factor (i.e. megacolon) or secondary interventions (i.e. drugs, endocrine, metabolic, neurologic or psychologic disorders); 2. History or evidence of gastrointestinal diseases (i.e. obstruction, cancer, inflammatory bowel diseases); 3. Previous abdominal surgery, except cholecystectomy, appendicectomy, tubal ligation and cesarean section; 4. Previous proctological or perianal surgery; 5. A constipation condition meeting the Rome III criteria for IBS or functional abdominal pain syndrome; 6. Pregnant or breast-feeding women; 7. Infection with enteric pathogen; 8. Usage of probiotics, prebiotics and/or synbiotics within the last month; 9. Usage of antibiotics and/or PPIs within the last 3 months; 10. Smoking or alcohol addiction within the last 3 months; 11. Uncontrolled hepatic, renal, cardiovascular, respiratory or psychiatric disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Defecation times per week;Stool form scale;Wexner constipation score;Gastrointestinal quality of life index;Geriatric depression scale; | — |
Countries
China
Contacts
Public ContactLi Yuwei
Tianjin Union Medical Center
Outcome results
None listed