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The median effective doses (ED50) of propofol with different doses of dexmedetomidine during hysteroscopic surgery

The median effective doses (ED50) of propofol with different doses of dexmedetomidine during hysteroscopic surgery

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000033220
Enrollment
Unknown
Registered
2020-05-24
Start date
2020-05-22
Completion date
Unknown
Last updated
2020-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysteroscopic surgery

Interventions

Control group:normal saline
D0.6 group:0.6ug/kg dexmedetomidine
D0.4 group:0.4ug/kg dexmedetomidine
D0.8 group:0.8ug/kg dexmedetomidine
D0.8 group:1.0ug/kg dexmedetomidine

Sponsors

Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: From June 2020 to December 2020, 150 ASA I-II female patients aged 18 to 60 years will be selected from the Affiliated Hospital of North Sichuan Medical College for elective hysteroscopic surgery.

Exclusion criteria

Exclusion criteria: 1. Patients who are allergic to propofol and dexmedetomidine; 2. Patients with heart block; 3. Patients with respiratory and circulatory diseases, endocrine diseases; 4. Patients with liver and kidney dysfunction; 5. Patients who use sedatives and opioids in the near future; 6. Patients with sleep disorders; 7. Patients who abuse drugs or alcohol; 8. Patients with BMI 24.

Design outcomes

Primary

MeasureTime frame
Target controlled infusion concentration of propofol and its response to hysteroscopic dilatation;

Secondary

MeasureTime frame
NIBP;HR;SpO2;Ramsay;RR;pain;operation time;anesthesia time;awake time;the dose of propofol;

Countries

China

Contacts

Public ContactWan Fangjun

Affiliated Hospital of North Sichuan Medical College

wfjlxy006@126.com+86 13458253172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026