Osteoporosis, diabetes
Conditions
Interventions
Diabetes mellitus with osteoporosis group:Zoledronic acid
Diabetes mellitus group:Zoledronic acid
Sponsors
Department of Endocrinology, Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Diagnostic criteria of osteoporosis: 1. Patients with brittle fracture of hip or vertebral body; 2. Patients whose t value of axial BMD measured by DXA or 1 / 3 of distal radius BMD is less than - 2.5; 3. BMD measurement was consistent with BMD reduction (- 2.5 < T value < - 1) + brittle fracture of proximal humerus, pelvis or distal forearm.
Exclusion criteria
Exclusion criteria: 1. Patients with type 1 diabetes mellitus, special type of diabetes mellitus, gestational diabetes mellitus, diabetes mellitus of unknown type; patients with acute complications of type 2 diabetes mellitus, severe infection, hematopathy and other serious disorders of the body metabolism; 2. Patients with GFR of less than 45ml / min / 1.73 m2 and severe renal damage, end-stage renal disease or dialysis; 3. The pregnant or lactating women have had malignant tumor within 2 years and acute cerebrovascular accident within half a year. 4. Patients with abnormal thyroid function, hyperthyroidism and hypothyroidism; 5. Patients with type 1 or type 2 diabetes were excluded from the retrospective study; 6. Patients who have used glucocorticoids within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycated hemoglobin;Venous blood glucose;Fructosamine;Fasting insulin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fructosamine;Bone metabolism markers; | — |
Countries
China
Contacts
Public ContactXu Ling
Affiliated Hospital of Southwest Medical University
Outcome results
None listed