Multiple myeloma
Conditions
Interventions
Sponsors
the Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Patients diagnosed with multiple myeloma have no effective treatment options (such as autologous or allogeneic stem cell transplantation) and have limited prognosis with existing therapies ( 12 weeks; 3. Multiple myeloma diagnosed by physical examination, pathological examination, laboratory examination and imaging; 4. Patients with multiple myeloma chemotherapy failure; 5. Patients with multiple myeloma recurrence; 6. ALT, AST 50%; 9. Failure of autologous stem cell and allogeneic stem cell transplantation; 10. Not suitable for stem cell transplantation conditions or for abandoning transplantation due to conditional restrictions; 11. Blood can be taken intravenously without other contraindications for leukapheresis; 12. Can understand and voluntarily sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. pregnant or lactating women, or women with a pregnancy plan within six months; 2. infectious diseases (such as HIV, active tuberculosis, etc.); 3. Active hepatitis B or C infection; 4. Feasibility assessment screening demonstrates that transfection of targeted lymphocytes is < 10% or insufficiently amplified by CD3/CD28 co-stimulation (< 5 fold); 5. Vital signs are not normal and cannot be matched with the examiner; 6. Those who have mental or mental illnesses that cannot be combined with treatment and efficacy evaluation; 7. Highly allergic or have a history of severe allergies, especially those who are allergic to IL-2; 8. Systemic infections or localized serious infections require anti-infective treatment of subjects; 9. Combine dysfunction of important organs such as heart, lung, brain and kidney; 10. Subjects with severe autoimmune diseases; 11. The doctor believes that there are other reasons that cannot be included in the treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR; | — |
Countries
China
Contacts
Public ContactLi Zhenyu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed