Acute Ischemic Stroke
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients included in AIS. Inclusion criteria: 1. The age of the patients was over 18 years old; 2. Patients were admitted to the hospital (stroke center) within 6 hours after symptoms appeared; 3. After admission, the patient's physical examination was in accordance with the AIS diagnostic criteria, and finally confirmed by CT or MRI. The symptoms of AIS conform to one or more of the following: 1. Sudden weakness or numbness of one limb, with or without facial numbness; 2. The angle of mouth is askew; 3. Unclear or aphasia; 4. Eyeball gaze; 5. Loss of vision or blurred vision; 6. Vertigo with nausea and vomiting; 7. Severe headache or vomiting that has not occurred before; 8. Disturbance of consciousness or convulsion of limbs. 9. Initially diagnosed in community hospital and confirmed as AIS patient. Patients with AIS undergoing intravenous thrombolysis or intravascular therapy will be included in the statistical analysis to evaluate the intervention effect.
Exclusion criteria
Exclusion criteria: 1. Patients with Mrs score > 1 before this stroke; 2. Patients with preoperative CT plain scan aspect score of 0-6; 3. Patients with intracranial hemorrhage: cerebral hemorrhage, subarachnoid hemorrhage, etc; 4. Patients with contraindications of intravenous thrombolysis / intravascular therapy; 5. Patients who are unable to cooperate to complete the study; 6. Thrombocytopenia or neutropenia in patients with coagulation disorder or history of systemic hemorrhage History; 7. In patients with chronic liver disease and liver and kidney dysfunction, ALT increased (more than 3 times of the upper limit of normal value) and serum creatinine increased (more than 2 times of the upper limit of normal value); 8. For patients with serious cardiopulmonary disease, the researchers think it is not suitable to participate in this study; 9. Patients with bradycardia (heart rate lower than 60 beats / minute) and sick sinus syndrome; 10. Patients whose life expectancy is less than 3 months or who are unable to complete the study for other reasons; 11. Patients who have a history of drug allergy or food allergy and who are known to be allergic to the drug ingredients in this study; 12. Patients with DSA taboo, severe contrast agent allergy or iodine contrast agent absolute taboo; 13. Women of childbearing age who are negative in pregnancy test but refuse to take effective contraceptive measures, pregnant or lactating women Female; 14. Patients who were unable to complete the study due to mental disorders, cognitive or emotional disorders; 15. Patients who were considered unsuitable by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence - intravenous thrombolysis time / femoral artery puncture time;NIHSS score at discharge;MRs score at 3 months;; | — |
Countries
china
Contacts
Jingjiang people's Hospital / Shaoxing Second Hospital