Inter-trochanteric Fracture
Conditions
Interventions
control group:placeb
single administration group:15mg/kg of tranexamic acid with 100ml saline intravenously 1 hour preoperatively
twice administration group:15mg/kg of tranexamic acid with 100ml saline intravenously 1 hour preoperatively and saline at a dose of 100ml intravenously 5 hours postoperatively
Sponsors
Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patient diagnosed unilateral inter-trochanteric fracture treated with PFNA; 2. patient treated with PFNA for the first time; 3. no major trauma or surgical history within 6 months before operation; 4. no anemia, no abnormal liver or kidney function before the injury; 5. patient with free autonomous behavioral ability to cooperate with scale determination.
Exclusion criteria
Exclusion criteria: 1. pathological fracture; 2. with other trauma or operation in sick hip or femur for the past time; 3. mutiple fractures or simple inter-trochanteric fracture with traumatic hemorrhage in other area; 4. anaphylaxis to TXA or contraindications specified in the drug instructions; 5. previous history of cerebral infarction or myocardial infarction; 6. use anticoagulants previously or currently; 7. previous or current history of PE or DVT; 8. overlaping of perioperative and menstrual periods in female patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine; | — |
Secondary
| Measure | Time frame |
|---|---|
| coagulation parameters;operation time;intraoperative blood loss;postoperative drainage volume;postoperative transfusion volume;postoperative transfusion rate;postoperative complications; | — |
Countries
China
Contacts
Public ContactZhao Gang
Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed