Depression
Conditions
Interventions
simple propofol group:Use propofol as the only anesthetic
simple dextroketamine group:D-Ketamine as the only anesthetic
Sponsors
The Third Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
14 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. The patients and their families participated in the study knowingly and voluntarily, and signed the informed consent; 2. Depression patients who were hospitalized in the Department of psychiatry and were first treated with ECT; 3. Age: 16-55 years old, gender unlimited.
Exclusion criteria
Exclusion criteria: Patients meeting one of the following conditions are not included in the study: 1. Patients with other important organ dysfunction: including severe liver and kidney function abnormality, brain organic disease, NYHA >= grade III, coagulation function abnormality, poor control or untreated hypertension, hyperthyroidism, intracranial hypertension, intraocular pressure rise, etc; 2. Patients with contraindications of propofol and ketamine; 3. Patients who have participated in clinical studies related to other drugs of abstinence depression in the first three months; 4. Patients who are not suitable for inclusion in some special circumstances.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Pressure;heart rate;RASS score;Time from completion of anesthesia to waking up;Time from completion of anesthesia to recovery of swallowing reflex;Time from completion of anesthesia to leaving the treatment room; | — |
Countries
China
Contacts
Public ContactShaoli Zhou
The Third Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed