Sepsis
Conditions
Interventions
early stage CRRT group and non early stage CRRT group:N/A
Sponsors
Union Hospital Affiliated to Fujian Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: From January 2010 to June 2019, intensive care unit (ICU) of Fujian Medical University Affiliated Union Hospital and Fujian provincial hospital were admitted to patients with septic shock and sepsis related left ventricular dysfunction. They received color Doppler echocardiography within 7 days and early continuous renal replacement therapy within 24 hours. Color Doppler echocardiography is performed by a professional physician. 1. Sepsis diagnosis standard: sepsis 3.0 of SCCM / ESICM in 2016 is the latest sepsis diagnosis standard, which conforms to the total score of sofa caused by infection >= 2 points (for patients with unknown basic organ dysfunction, the baseline SOFA score is 0); 2. Diagnostic criteria for septic shock: the latest diagnostic criteria for septic shock in sepsis 3.0 of SCCM / ESICM in 2016 is in line with the diagnosis of sepsis with persistent hypotension. Even after receiving adequate volume resuscitation treatment, booster drugs are still needed to maintain the mean arterial pressure (map) of >= 65mmhg, and the blood lactate level is > 2mmol / L (18mg / dl). 3. Diagnostic criteria for left ventricular dysfunction: Patients with septic shock were confirmed after admission to ICU. Once in 7 days after shock, transthoracic echocardiography indicated that left ventricular systolic function decreased, and ejection fraction EF was less than 50%. According to the classification of left ventricular diastolic dysfunction by American Society of echocardiography, level II-IV was considered as left ventricular diastolic dysfunction.
Exclusion criteria
Exclusion criteria: 1. Patients under 18 years old; 2. Patients with previous heart failure or asymptomatic left ventricular dysfunction; 3. Patients with previous DCM; 4. Patients with chronic pulmonary heart disease; 5. Patients with recent acute coronary syndrome (< 1 week); 6. Pregnant objects; 7. Patients with moderate to severe valvular heart disease; 8. Patients with previous congenital heart disease; 9. Patients with cardiac arrest, poisoning, rhabdomyolysis, metabolic disorder, heart failure or renal failure outside the hospital, type 1 respiratory insufficiency requires hemodialysis; 10. Patients who need hemodialysis for septic acute renal damage; 11. Patients with chronic renal insufficiency, dialysis or hemodialysis, and active malignant tumors before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| acute kidney injury; | — |
Countries
China
Contacts
Public ContactWenwei Wu
Union Hospital Affiliated to Fujian Medical University
Outcome results
None listed