Actinic keratoses
Conditions
Interventions
experimental group:Painless photodynamic therapy
control group:Conventional photodynamic therapy
Sponsors
Shanghai Dermatology Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosed with AK (OLSEN classification grade I, II, III), aged > 18 years (Because no dosing or adverse event data are currently available on the use of topical aminolevulinic acid in patients <18 years of age, children are excluded from this study); 2. All patients are unfit and reluctant to undergo surgery for any reasons, and volunteered to participate in the study and ability to understand and the willingness to sign a written informed consent. Patents are willing to pay for the treatment, and agreed to take a picture of the skin lesions.
Exclusion criteria
Exclusion criteria: 1. Those who have been treated with ALA-PDT and those who have applied any other impact study within 12 weeks; 2. Patients with other diseases that may affect the efficacy evaluation, such as other light skin diseases; 3. Patients taking phototoxic or photosensitive drugs within 8 weeks; 4. Patients with clinically and / or pathologically proven tumor invasion to other organs or tissues; 5. Patients with severe immune dysfunction; 6. Patients with scar constitution; 7. Patients with known skin photoallergy, porphyria or allergy to Ala, light or lidocaine; 8. Those who suffer from serious internal diseases, psychological and mental diseases, infectious diseases or pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| complete clearance rate of AK lesions at 1 month after PDT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessment;Follow up the recurrence of AK lesions; | — |
Countries
China
Contacts
Public ContactXiuli Wang
Shanghai Dermatology hospital
Outcome results
None listed