Tuberculosis
Conditions
Interventions
liver injury group vs. non liver injury:Nil
Sponsors
Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed or clinically diagnosed as tuberculosis according to the health industry standard of the people's Republic of China - tuberculosis diagnosis (ws288-2017); 2. Patients between 18-75 years old; 3. Patients with normal liver function before admission; Four Patients who do not use drugs other than antituberculosis drugs with clear liver damage (such as paracetamol, indomethacin, cyclophosphamide, cisplatin, carboplatin, methotrexate, statins, estrogens, oral contraceptives, amiodarone, warfarin, chloromycetin, roxithromycin, ketoconazole, sulfanilamide, promethazine, cimetidine, etc.); paracetamol When phenol is used for cooling, the dosage of phenol in a single day should not exceed 4G or 2G. If phenol is used continuously for no more than 7 days, it can still be considered as a group; 5. Patients who sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with other diseases affecting liver function (such as HAV, HBV, HCV, HIV positive, fatty liver, alcoholic liver, liver cancer, liver cirrhosis, etc.); 2. Patients who do not use isoniazid and other first-line anti tuberculosis drugs for treatment; 3. The patients who were followed up for 6 months were not accepted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GSTs;Blood concentration of anti-tuberculosis drugs; | — |
Countries
China
Contacts
Public ContactXingxing Li
Sichuan People's Hospital Affiliated to University of Electronic Science and Technology
Outcome results
None listed