Correlation between RNA and inflammatory cytokines in peripheral blood circulation and cognitive dysfunction after major orthopedic surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000033001

Enrollment

Unknown

Registered

2020-05-17

Start date

2020-06-01

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip and knee replacement

Interventions

POCD group:N/A

non-POCD group :N/A

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Elderly patients undergoing major orthopedic surgery with general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients with previous mental history and current nervous system diseases; 2. Patients with positive physical signs in nervous system examination; 3. The left ventricular ejection fraction (EF) was less than 40%; 4. Patients who refused / failed to complete the preoperative cognitive function test; 5. MMSE score (Full Score: 30): illiterate < 17, primary < 20, middle school and above < 24.

Design outcomes

Primary

Measure	Time frame
RNA;	—

Secondary

Measure	Time frame
IL;CRP;TNF-a;	—

Countries

China

Contacts

Public ContactChen Chan

West China Hospital of Sichuan University

scuwchchanchen@foxmail.com+86 18980606260

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 12, 2026