Multi-center cohort study on the correlation between female vaginal microecological flora and cervical and vaginal diseases

Gardnerella vaginalis lipopolysaccharide promote the integration of high-risk HPV to host genome by inhibition E2 protein mediated by TLR4/NF-?Bp65 signaling pathway

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000032981

Enrollment

Unknown

Registered

2020-05-17

Start date

2020-05-17

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Lesions

Interventions

case series:N/A

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and older; 2. Previous sexual life history; 3. Signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Women during pregnancy or 6 months after childbirth; 2. Patients with previous cervical lesions; 3. Those who have previously undergone cervical-related surgery; 4. Refuse or fail to cooperate with follow-up.

Design outcomes

Primary

Measure	Time frame
vaginal microecological testing;HPV DNA;cervical cytology;Histopathological results of cervix uteri;	—

Countries

China

Contacts

Public ContactBinhua Dong

Fujian Provincial Maternity and Children's Hospital

dbh18-jy@126.com+86 0591-87558732

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026