Total knee arthroplasty (Knee osteoarthritis)
Conditions
Interventions
A:Adductor canal block combined with iPACK (ropivacaine)
B:Adductor canal block combined with iPACK (cocktail)
Sponsors
Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) The patients undergoing TKA; (2) Normal platelet and coagulation function preoperatively; (3) Normal intravenous ultrasound in the lower extremities preoperatively; (4) To be able to and willing to provide signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Systemic infections such as pulmonary infection or urinary tract infection are not controlled preoperatively; (2) Abnormal immune function or combined immune-related disease preoperatively; (3) Abnormal inflammatory index preoperatively (C-reactive protein > 20 mg/L); (4) Abnormal fibrinolysis index preoperatively (FDP > 5mg/L); (5) Discontinuation of oral anticoagulants or aspirin less than 1 week; (6) Allergy to tranexamic acid (TXA) or dexamethasone or have contraindications; (7) Patients at high risk of thrombosis; (8) History of deep vein thrombosis (VTE, calf muscle vein thrombosis or superficial vein thrombosis, pulmonary embolism); (9) Serious liver and kidney dysfunction.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Morphine consumption;Quadriceps muscle strength;Walking distance;Range of motion;PONV;color Doppler Ultrasonic (CDU) examination in lower extremity;SF-12;EQ-5D;Satisfaction scores;Sleep quality;Time for First Analgesic Request;Opioid-Related Adverse Effects;Ambulation time;KSS; | — |
Primary
| Measure | Time frame |
|---|---|
| VAS pain score; | — |
Countries
China
Contacts
Public ContactZongke Zhou
West China Hospital, Sichuan University
Outcome results
None listed