Renal Cell Carcinoma
Conditions
Interventions
Case series:SBRT
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >=18 years who voluntarily participated in the clinical study; 2. Patients whose nephrotic focus has been treated or can be treated at the same time; 3. Patients with ECoG score of 0-2; 4. Patients whose life expectancy is more than 3 months; 5. Patients with total metastasis <=5 and the largest tumor diameter <=6cm; 6. Patients who received first-line treatment for metastatic renal cancer for 3 months or more; according to the recist-1.1 evaluation standard, PR, Cr or SD curative effect has been obtained before oligoprogression; 7. Oligo progressive lesions should meet the following conditions: < 3 progressive lesions, and progressive lesions can meet any of the following conditions: new metastatic lesions appear, which can be evaluated according to the RECIST standard; compared with the best curative effect, the longest diameter of the original metastatic lesions increases by 20% and at least 5mm; 8. Safe SBRT can be obtained in all the oligometastases.
Exclusion criteria
Exclusion criteria: 1. Patients with radiotherapy contraindications; 2. Patients who have previously received radiotherapy at the site requiring SBRT treatment; 3. It is impossible to treat all patients with oligoprogressive lesions; 4. MRI images showed obvious compression of spinal cord and corresponding symptoms of nerve compression, and the patients needed emergency decompression; 5. Patients with liver and brain metastasis; 6. Patients who have received more than one-line systematic treatment for metastatic renal cancer in the past: targeted drug / immune / cytokine therapy; 7. Patients with other untreated malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Local control;Time to next-line therapy;Overall survival;Toxicity;Quality of life; | — |
Countries
China
Contacts
Public ContactLiru He
Sun Yat-sen University Cancer Center
Outcome results
None listed