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A randomized controlled trial for the efficacy and safety of artemisinin-pipequine tablets in the treatment of the mild and common type novel coronavirus pneumonia (COVID-19) patients whose nCoV Nucleic acid did not turn negative after treated by hydroxychloroquine and Abidor

A randomized controlled trial for the efficacy and safety of artemisinin-pipequine tablets in the treatment of the mild and common type novel coronavirus pneumonia (COVID-19) patients whose nCoV Nucleic acid did not turn negative after treated by hydroxychloroquine and Abidor

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000032915
Enrollment
Unknown
Registered
2020-05-15
Start date
2020-05-07
Completion date
Unknown
Last updated
2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Novel Coronavirus Pneumonia (COVID-19)

Interventions

Experimental group:Taking artemisinin-piperaquine
Control group:Symptomatic treatment with non-antiviral drugs

Sponsors

Hongqi Hospital Affiliated to Mudangjiang Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 2 to 65 years old, and signed informed consent; 2. According to the diagnostic criteria of the "New Coronavirus Pneumonia Diagnosis and Treatment Program (Trial Version 7)" issued by the National Health and Health Commission, those who have been diagnosed with CoVID-19 of light and common type and have been treated with hydroxychloroquine and Abidol but nCoV Nucleic acid did not turn negative. The specific diagnostic criteria are as follows: (1) light type: The clinical symptoms are mild, and there is no pneumonia manifestation in imaging; (2) Common type: It has fever, respiratory tract and other symptoms. Pneumonia can be seen on imaging; (3) The patient who have been diagnosed with CoVID-19 of light and common type and have been treated with hydroxychloroquine and Abidol but nCoV Nucleic acid did not turn negative.

Exclusion criteria

Exclusion criteria: 1. Pregnant women within 3 months of pregnancy; 2. Patients with liver and kidney disease and those with liver and kidney injury 3. Patients with blood diseases (such as leukopenia, thrombocytopenia, etc.). 4. Electrocardiogram prompting patients with severely extended QT.

Design outcomes

Primary

MeasureTime frame
Tolerance;Viral load of nCoV;Blood routine;Immunological examination;Blood liver and kidney function test;Myocardial enzyme biochemical examination;ECG examination;Urine routine;body temperature;pulse;Breathe;blood pressure;CT examination of the lungs;

Countries

China

Contacts

Public ContactFengjie Xie

Hongqi Hospital Affiliated to Mudangjiang Medical University

mdjxfj1971@126.com+86 13514563699

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026