Chronic obstructive pulmonary disease (COPD)
Conditions
Interventions
frequent acute aggravation COPD group:Nil
non frequent acute aggravation COPD group:Nil
without basic lung disease gruop:Nil
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-85 years without gender limitations; 2. Never smoke or quit smoking for more than 1 year; 3. Subjects who meet the diagnostic criteria of Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2020; 4. No application of antibacterial or antiviral drugs in the past 1 month; 5. Subjects who obtain and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with bronchial asthma, tumor, tuberculosis or other chronic consumptive diseases; 2. Patients with severe circulatory system diseases, hematological system disease, or autoimmune diseases; 3. Invasive ventilation through tracheal intubation after admission; 4. Evidently limited mobility due to severe osteoarthropathy; 5. Patients with severe mental illness or cognitive dysfunction; 6. Subjects who could not cope with clinical observation and sample collection due to poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbial species via NGS;Microbial species via 16s rDNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive detection rate of microorganism;CRP;PCT;ESR;IL-6;SAA;IgA;IgG;IgM;T lymphocyte subsets;ALB;Stool routine;Sputum smear;Sputum culture; | — |
Countries
China
Contacts
Public ContactYinji Xu
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed