Sepsis
Conditions
Interventions
Experimental group:In the intervention group, the patient will receive a loading dose of 1 g meropenem in 20ml of normal saline infused by central line over 30 minutes followed immediately by 0.5 g of
Control group:In the control group, the patient will receive 0.5 g of meropenem over 30 minutes every 6 hours.
Sponsors
Guangzhou First People's Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged >=18 years; 2. Patients with severe sepsis or septic shock who received CRRT; 3. Meropenem was used to treat infectious attack; 4. Written informed consent of the patient or guardian.
Exclusion criteria
Exclusion criteria: 1. Pregnant / nursing patients; 2. Patients allergic to meropenem; 3. Patients were randomly assigned to receive meropenem 24 hours before treatment; 4. Patients who only receive palliative or supportive treatment at the time of qualification evaluation; 5. Patients with liver function impairment (child Pugh C); 6. Patients participating in other clinical trials 7. Patients who could not measure the concentration of meropenem within 24 hours after randomization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The fraction of pharmacometric target attainment;Clinical response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical response;Microbiological outcomes;ICU mortality;hospital mortality;Duration of meropenem treatment;the total dose of meropenem;Number of days free of CRRT therapy;SOFA (Sequential Organ Failure Assessment) scores;C reactive protein;white blood cell;PCT; | — |
Countries
China
Contacts
Public ContactZhang Chen
Guangzhou first people's Hospital
Outcome results
None listed