Meige syndrome
Conditions
Interventions
STN DBS group:Accept bilateral STN DBS
GPi DBS group:Accept bilateral GPi DBS
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as primary Meige syndrome; 2. Patients who fail to control the symptoms and seriously affect the quality of life after the treatment of oral drugs and botulinum toxin; 3. Patients in good health except for dystonia; 4. Patients with normal screening results by MMSE; 5. The subjects or their families can fully understand the treatment and sign the informed consent; 6. The patients with good compliance can cooperate with the patients who complete the postoperative follow-up requirements.
Exclusion criteria
Exclusion criteria: 1. Patients with abnormal changes of basal ganglia on imaging; 2. Patients with serious progressive nervous system, cardiovascular system, respiratory system or digestive system diseases; patients with unstable mental state; 3. Patients with contraindications to surgery or anesthesia, such as taking anticoagulant and antiplatelet drugs for a long time; 4. Women who plan to be pregnant, or are in pregnancy and lactation; 5. Patients who have or need other implantable devices, such as pacemakers, defibrillators, cochlear implants and chiropractic root stimulators; 6. Patients who need 3.0T MRI for many times in the future clinical trials due to their own reasons; 7. Patients who have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Burke- fahn-marsden Dystonia Rating scale (BFMDRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination, MMSE;Montreal Cognitive Assessment, MoCA;Hamilton Dpression Scale, HAMD;Hamilton Anxiety Scale, HAMA;Health-related quality of life (QOL), SF-36; | — |
Countries
China
Contacts
Public ContactWei Wang
West China Hospital, Sichuan University
Outcome results
None listed