Cervical Cancer
Conditions
Interventions
control group:radical surgery
experimental group:radical surgery and para-aortic lymphadenectomy
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of early cervical cancer (stage IB2, IB3, IIA1, or IIA2); 2. The pathology of cervical biopsy or LEEP is cervical squamous cell carcinoma, cervical adenosquamous cell carcinoma or cervical adenocarcinoma; 3. Aged 18 - 70, ECOG performance status 0 - 2; 4. Without neoadjuvant chemotherapy or radiotherapy before operation; 5. Para-aortic lymph nodes are negative before operation by CT, MRI and/or PET-CT; 6. Para-aortic lymph nodes are negative during Intraoperative exploration; 7. Adequate liver and renal function; 8. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Can't accept operation due to various contraindications; 2. Suffering from other malignant tumors or other serious medical and surgical complications; 3. Extra-cervical metastasis detected by CT, MRI and/or PET-CT; 4. Unable to cooperate with regular follow-up due to psychological, social, family and geographical reasons; 5. Participated in other clinical trials; 6. Drug addiction, chronic alcoholism or AIDS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS;PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of surgical complications;Metastasis rate of para-aortic lymph nodes;Quality of life; | — |
Countries
China
Contacts
Public ContactWu Xiaohua
Fudan University Shanghai Cancer Center
Outcome results
None listed