hip fracture
Conditions
Interventions
Group A:2.0g oral-placebo will be administrated every 8 hours from admission day to the day before the surgery while 2.0g oral TXA will be administrated every 8 hours from POD1 to POD3
Group B:2.0g oral-TXA will be administrated sequentially every 8 hours from admission day to POD3
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with a hip fracture, treated surgically with internal fixation or arthroplasty.
Exclusion criteria
Exclusion criteria: (1) Complicated with multiple fractures or open fractures; (2) Active bleeding (like gastrointestinal bleeding, cerebral hemorrhage, etc.); (3) Systematic thromboembolism (deep vein thrombosis, pulmonary thrombosis, etc.); (4) Coagulation dysfunction; (5) Combined with serious neuromuscular diseases; (6) Allergic to TXA.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total blood loss;hidden blood loss;intraoperative blood loss ;fibrinolysis index (D-Dimer, FDP);inflammatory index (PCT, CRP, ESR, IL-6, IL-8, IL-10, TNF-a); | — |
Secondary
| Measure | Time frame |
|---|---|
| coagulation indicator (PT, APTT, INR);TEG;antifactor Xa activity ;Hb drop;transfusion;range of motion;ecchymosis;length of stay;VAS score; | — |
Countries
China
Contacts
Public ContactWei Huang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed