postoperative lung injury
Conditions
Interventions
Group 1:low tidal volume ventilation during operation
Group 2:low tidal volume with alveolar recruitment maneuvers ventilation during operation
Group 3:low tidal volume with PEEP and alveolar recruitment maneuvers ventilation during operation
Sponsors
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years; 2. ASA classification I-III; 3. Undergoing total knee arthroplasty surgery and general anaesthesia expected to be extubated; 4. Postoperative Pneumonia Risk Index Scores >= two risk class; 5. Written inform consent.
Exclusion criteria
Exclusion criteria: 1. Overweight (BMI >= 35kg/m2); 2. Respiratory infection within 1 months before surgery; 3. Previos lung surgery; 4. Use of mechanical ventilation within 2 months before surgery; 5. Any neuromuscular disease; 6. Congestive heart failure or significant cardiac dysfunction (LVEF < 50%); 7. Diagnosed COPD or sleep apnea; 8. Preoperative pulmonary function test suggests severe impairment of pulmonary function. 9. Moderate or severe anemia; 10. Severe liver disease (such as liver failure) or chronic renal failure (glomerular filtration rate < 30 ml/min).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood gas analysis;the lung ultrasound scores (LUSs); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications;SP02;Lung compliance; | — |
Countries
China
Contacts
Public ContactWang Sheng
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
Outcome results
None listed