The application of butorphanol nasal spray in epidural labor analgesia and the effect of single nucleotide polymorphism of opioid receptor gene on analgesia: a randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000032778

Enrollment

Unknown

Registered

2020-05-10

Start date

2020-06-18

Completion date

Unknown

Last updated

2020-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnant women

Interventions

control group:Saline nasal spray

experimental group:butorphanol nasal spray

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. ASA I or II; 2. Single fetal head position >= 37 weeks of gestation (including parturient and primary parturient as well as parturient with spontaneous and oxytocin induced labor); 3. Women with labor pain relief needs.

Exclusion criteria

Exclusion criteria: 1. Not for people with butorphanol allergy; 2. A woman who has been taking oral opioids for a long period of time after receiving intravenous opioids during hospitalization; 3. A woman in fetal distress; 4. After the administration of the drug and before the seventh uterine contraction, any of the following conditions occurred, the patient's data was deleted from the analysis, and another patient was re-entered and randomized: artificial rupture of the membrane; There was a change in the rate of infusion of oxytocin or oxytocin infusion; All puerpera were opened within 1 hour after administration. 5. Absolute and relative contraindications to intraspinal anesthesia and analgesia; 6. Serious diseases of the heart, lungs, liver, kidney, endocrine or nervous system; 7. Systemic analgesics are currently used.

Design outcomes

Primary

Measure	Time frame
Pain intensity score;Emotional score;Maternal coordination during epidural puncture;Gene polymorphism detection;Sedation scores;Nausea and vomiting score;Time of onset of epidural labor analgesia;Labor time;Total amount of epidural analgesics;The number of times the woman presses and the effective number;Mode of delivery;The Apgar score was measured at 1 minute and 5 minutes in newborns;Umbilical cord arterial blood PH;The occurrence of adverse reactions such as nausea and vomiting, postpartum urinary retention and pruritus within 24h after delivery;Lactation initiation time;	—

Measure

Time frame

Pain intensity score;Emotional score;Maternal coordination during epidural puncture;Gene polymorphism detection;Sedation scores;Nausea and vomiting score;Time of onset of epidural labor analgesia;Labor time;Total amount of epidural analgesics;The number of times the woman presses and the effective number;Mode of delivery;The Apgar score was measured at 1 minute and 5 minutes in newborns;Umbilical cord arterial blood PH;The occurrence of adverse reactions such as nausea and vomiting, postpartum urinary retention and pruritus within 24h after delivery;Lactation initiation time;

—

Countries

China

Contacts

Public ContactJing Sun

Affiliated Shenzhen Maternity and Child Healthcare Hospital

187244758@qq.com+86 13501597110

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026