Bladder Cancer
Conditions
Interventions
Sponsors
Department of Department of Urology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. From 2008 to 2018, TURBT was performed in our hospital, during which tumor tissues were collected and stored in our biological sample bank; 2. The patients with myometrial infiltrative urothelial carcinoma were evaluated clinically and pathologically; 3. Patients without metastasis found in clinical and imaging examination within 3 months after operation (bone scan, MRI or CT plain scan + enhancement); 4. Patients with clinical stage >=T2a; 5. Patients younger than 80 years old; 6. Patients with preoperative life expectancy >=5 years; 7. Patients who met the following criteria: neutrophils >=1500 / mm^3, platelets >=100000/mm^3, bilirubin 60ml/min); 8. Prior to sample retention, the patient has signed the informed consent for sample retention in biological sample bank of Renji Hospital.
Exclusion criteria
Exclusion criteria: 1. Patients with active infection, history of thromboembolism and uncontrolled cardiovascular complications before operation; 2. Patients with a history of cancer other than basal cell carcinoma of the skin; 3. Any patient with a history of disease that is not consistent with the treatment plan; 4. Patients who have previously received chemotherapy, radiotherapy, endocrine therapy and targeted therapy for other tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC area, sensitivity and specificity of pathological complete response rate after radical operation;AUC area, sensitivity, and specificity of pathological partial response;DNA profile;RNA profile;IHC; | — |
Secondary
| Measure | Time frame |
|---|---|
| AUC area, sensitivity, and specificity benefiting from the overall survival rate of neoadjuvant chemotherapy;The area, sensitivity and specificity of AUC benefiting from disease-free survival;The area, sensitivity and specificity of AUC benefiting from disease-related mortality; | — |
Countries
China
Contacts
Public ContactRuiyun Zhang
Department of Urology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed