Pelvic Floor Dysfunction
Conditions
Interventions
Estrogen cream group:use the vaginal estrogen cream along with the pessary
placebo group:use the vaginal cream without estrogen along with the pessary
Sponsors
Beijing Union Medical College Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Patients may choose to be included in the study when all of the following conditions are met: 1. Symptomatic pop (stage II, III or IV); 2. Postmenopausal (women after hysterectomy need serum FSH > 40 IU / L); 3. The subjects who have successfully tried to wear the circular uterine tray; 4. Participants in clinical trials, follow-up and filling in questionnaires; 5. Patients and their families can understand the research plan and are willing to participate in the research, and provide written informed consent.
Exclusion criteria
Exclusion criteria: Patients cannot be selected for clinical study if they have any of the following conditions: 1. Patients with acute infection of the internal and / or external reproductive tract; 2. Contraindications of vaginal estrogen include known or suspected estrogen dependent malignancies (endometrial cancer, melanoma) and endometrial hyperplasia (bilateral thickness of the endometrium is 5mm), thrombophlebitis or thromboembolic diseases, vaginal irregular bleeding with unknown diagnosis, known or suspected breast, and allergy to any component of estrogen cream; 3. Patients with suspected or untreated tumors of the lower genital tract; 4. Patients with genital fistula; 5. Patients with abnormal increase of abdominal pressure (such as ascites, tumor); 6. Patients with life expectancy less than 1 year; 7. Patients who received hormone replacement therapy in the past 3 months. 8. Participating urine volume is more than 250ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Satisfactory continuous using rate in one year after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| treatment effect;Complication rate; | — |
Countries
China
Contacts
Public ContactZhu Lan
Beijing Union Medical College Hospital
Outcome results
None listed