inactive HBV infectio
Conditions
Interventions
Experimental group:Peg IFN alpha 180ug/kg once every week for 48 weeks
control group:No treatment
Sponsors
The Fifth Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. HBsAg positive > 6 months, and HBsAg 40g/LINR 0.8-1.2; 6. WBC (4-10)x10^9/LPLT(100-300)x10^9/L; 7. LSM < 6.4kpa or G < 2, s < 2; 8. There was no antiviral treatment in the past year; 9. Aged 18-60 years; 10. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Other liver diseases (including HCV / HDV / HIV infection, autoimmune liver disease, metabolic liver disease, alcoholic liver disease, cirrhosis, liver or other system tumors, etc.); 2. It is not suitable for interferon treatment (including but not limited to autoimmune diseases, thyroid dysfunction, emotional disorders, having fertility requirements in recent two years, etc.); 3. Other events that the researchers believe should be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the clearence of HBsAg; | — |
Secondary
| Measure | Time frame |
|---|---|
| HBV DNA;the quantitation of HBsAg; | — |
Countries
China
Contacts
Public ContactSa Lv
The Fifth Medical Center of PLA General Hospital
Outcome results
None listed